Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical SH-4-54, Purity: ≥98%, CAS: 1456632-40-8, 5 mg
A STAT3 inhibitor (IC50 = 4.7 μM for STAT3 homodimer DNA binding activity); selectively inhibits STAT3 homodimer over STAT1 and STAT5 homodimer and STAT3:STAT1 heterodimer DNA binding in EGF-stimulated NIH3T3/hEGFR nuclear extracts containing activated STAT1, STAT3, and STAT5; decreases STAT3 iNOS, Survivin, and Bcl-2 promoter occupancy in MDA-MB-231 cells; inhibits growth of glioma, breast, and prostate cancer cell lines that express constitutively active STAT3 (IC50s = 1-7.4, 3.8-4.5, and 5.3-5.8 μM, respectively); inhibits tumor growth in the U251MG glioma and MDA-MB-231 breast cancer mouse xenograft models at 3 mg/kg per day
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Cayman Chemical C22 Ceramide (d18:1/22:0), Purity: ≥95%, CAS: 27888-44-4, 5 mg
A bioactive sphingolipid; forms small channels in liposomes, suggesting that acyl chain length is important in mitochondrial-mediated apoptosis; decreases the mitochondrial-to-cytosolic stress response in C. elegans following hsp-6 RNAi
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Medchemexpress LLC Pregnenolone monosulfate | 1247-64-9 | 99.96% | 1 ML
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Pregnenolone monosulfate is a powerful neurosteroid and the main precursor of various steroid hormones, including steroid ketones. It functions as a signaling-specific inhibitor of the cannabinoid CB1 receptor, inhibiting the effects of tetrahydrocannabinol (THC) that are mediated by CB1 receptors. It can protect the brain from cannabis intoxication and also acts as a TRPM3 channel activator and can weakly activate TRPM1 channels.
- Powerful neurosteroid
- Main precursor of various steroid hormones
- Signaling-specific inhibitor of cannabinoid CB1 receptor
- Inhibits THC effects mediated by CB1 receptors
- Protects the brain from cannabis intoxication
- TRPM3 channel activator
- Weakly activates TRPM1 channels
- For research use only
- Solid appearance, white to off-white color
- Initial source: Endogenous metabolite
- Structure classification: Steroids
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Medchemexpress LLC Eberconazole nitrate | 130104-32-4 | MFCD00896878 | 392.24 g/mol | C18H15Cl2N3O3 | 1 ML
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Eberconazole nitrate is an imidazole-class antifungal reagent supplied as a 10 mM solution in DMSO for laboratory research and analytical applications. It is used in vitro for antifungal testing and related studies.
- Imidazole-class antifungal reagent for in vitro studies.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- Molecular formula C18H15Cl2N3O3; molecular weight 392.24 g/mol.
- CAS number 130104-32-4.
- Intended for research and analytical applications; not for human therapeutic use.
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Cayman Chemical ANTIBODY S63845 500ug
An Mcl-1 inhibitor (Ki = 0.19 nM); induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = via mitochondrial apoptosis; acts synergistically with trametinib, lapatinib, PLX4032, and erlotinib to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively; reduces tumor volume in a MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner
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Medchemexpress LLC IDO-IN-12 100mg | 1888341-29-4 | 100 MG
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IDO-IN-12 is a small-molecule inhibitor of indoleamine 2,3-dioxygenase (IDO) disclosed in patent WO 2017181849 A1. It is supplied as a white to off-white solid for preclinical IDO pathway research and biochemical assays.
- Small-molecule IDO inhibitor for preclinical research.
- CAS number 1888341-29-4.
- Molecular formula C13H11BrFN5O3S.
- Molecular weight 416.23.
- Appearance white to off-white solid.
- Purity 99.22% (reported).
- Available in multiple sizes including 100 MG and solution formats.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solvent -80°C (6 months) or -20°C (1 month).
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Cayman Chemical Sparsentan, Purity: ≥98%, CAS: 254740-64-2, 25 mg
A dual antagonist of AT1 and ETA (Kis = 0.8 and 9.3 nM, respectively, for the human receptors); selective for these receptors over AT2 and ETB receptors (Kis = >10 µM for both); inhibits angiotensin II-induced pressor responses in conscious normotensive rats (ED50 = 3.6 µmol/kg, p.o); reduces mean arterial pressure in spontaneously hypertensive rats at 10, 30, or 100 µmol/kg per day, p.o.; reduces albuminuria and inhibits development of glomerulosclerosis in the gddY mouse model of IgA nephropathy when administered in the diet at 1,800 ppm
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Selleck Chemical LLC Resatorvid5mg
Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor ofToll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-? and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibitsautophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Cayman Chemical Chelidonine, Purity: ≥98%, CAS: 476-32-4, 5 mg
A benzophenanthridine alkaloid; induces Bcl-2- and caspase-dependent apoptosis in HepG2 human liver carcinoma cells (LD50 = 12 µM) and in Jurkat human T cells at 1 µM; downregulates hTERT expression, reduces telomerase activity, and induces cell senescence in HepG2 cells
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Cayman Chemical LSN2814617, Purity: ≥98%, CAS: 1313498-08-6, 25 mg
A positive allosteric modulator of mGluR5 receptors; potentiates glutamate-induced calcium mobilization in MCB3901 cells expressing human mGluR5 (EC50 = 52 nM); increases rat hippocampal mGluR5 receptor occupancy (ED50 = 13 mg/kg); increases wakefulness and decreases NREM and REM sleep in rats at 0.3, 1, and 3 mg/kg
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Medchemexpress LLC HY-W018171 500mg Medchemexpress, 3,5,6-Trichloro-2-pyridinol CAS:6515-38-4 Purity:>98%
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Medchemexpress, HY-W018171 500mg 3,5,6-Trichloro-2-pyridinol CAS:6515-38-4 3,5,6-Trichloro-2-pyridinol (TCPy) is the main degradation product of the herbicide Triclopyr and the insecticides Chlorpyrifos and Chlorpyrifos-methyl. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Selleck Chemical LLC Fmoc-Leu-d10 E8240-5MG
Fmoc-Leu-d10 is the deuterated form of Fmoc-Leu-OH Fmoc-Leu-OH is an intermediate used to protect leucine in solid phase peptide synthesis The peptide drugs synthesized by Fmoc-Leu-OH may have activities such as regulating insulin sensitivity
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Cayman Chemical FX1, Purity: ≥95%, CAS: 1426138-42-2, 1 mg
A BCL6 inhibitor (IC50 = ~35 μM); selective for BCL6 over a panel of 50 kinases at 10 μM; reduces recruitment of the BCL6 corepressor proteins SMRT and BCOR to the BCL6 target loci CDKN1A, CD69, and CXCR4 in a ChIP assay at 50 μM; represses growth of Farage, SU-DLH-6, DOHH-2, OCI-Ly7, RCK8, SU-DHL-4, OCI-Ly1, and SC-1 BCL6-dependent cell lines (GI50s = 16-54 μM); reduces tumor volume in an HBL-1 large B cell lymphoma mouse xenograft model at 50 mg/kg
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Cayman Chemical DTUN, 10 mg
A lipophilic hyponitrite radical initiator; initiates co-autoxidation of STY-BODIPY-embedded egg phosphatidylcholine liposomes at 0.2 mM; has been used in FENIX assays for the development of ferroptosis inhibitors and the study of antioxidants in lipid membranes
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TARGETMOL CHEMICALS INC PIOGLITAZONE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury. purity: 99%
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