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Filtered Search Results
Cayman Chemical TnshInon IIA 5mg
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A natural product with anti-inflammatory and cytotoxic activity; inhibits production of TNFα, IL-1β, IL-6, NO, INFγ, and expression of iNOS, and IL-12; blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways
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Selleck Chemical LLC Tacrine E4822-100MG
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Tacrine is a potent acetylcholinesterase (AChE) inhibitor It inhibits acetylcholinesterase(AChE) and butyrylcholinesterase(BChE) with an IC50 of 77 nM and 69 nM respectively It is used in the treatment of Alzheimer s disease (AD) also poisoning topoisomerases and inhibiting in vivo (mitochondrial)mtDNA synthesis
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Selleck Chemical LLC MYCi975 S8906-100MG
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MYCi975 (NUCC-0200975) is a potent selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction promotes MYC T58 phosphorylation and MYC degradation and impairs MYC driven gene expression MYCi975 exhibits potent anti-tumor activities
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Cayman Chemical BrIncIdofovIr 5mg
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A prodrug form of cidofovir; inhibits CMV, HSV-1, HSV-2, cowpox, and vaccinia virus replication in plaque reduction assays (EC50s = 0.0009, 0.06, 0.08, 0.6, and ~1 µM, respectively); decreases mortality in mouse models of cowpox or vaccinia virus infections at 6.7 or 5 mg/kg, respectively
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AdipoGen 3 8-DAPP
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Chemical. CAS 52009-64-0. Formula C19H15N3. MW 285.3. Synthetic. Phenyl-phenanthridine dye with a large pi-conjugated structure and strong luminescence. Used in the synthesis of rigid polyamides and fluorescent probes. DNA intercalator. Used as a chromatographic affinity ligand for the specific separation and purification of supercoiled plasmid DNA pDNA. It has been investigated for its anti-tumor and anti-viral properties.
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Selleck Chemical LLC OTSSP167 5mg 1431697-89-0 OTS167
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OTSSP167 (OTS167) is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Cayman Chemical ANTIBODY CYT387 10mg
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An ATP-competitive inhibitor of JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively); causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines; is efficacious in a mouse model of JAK2V617F-dependent myeloproliferative neoplasms
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Selleck Chemical LLC SLC13A5-IN-1 S0755-25MG
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SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5/NaCT) It completely blocks the uptake of 14 C-citrate and has the potential for the treatment of metabolic and/or cardiovascular diseases
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Selleck Chemical LLC Vafidemstat S9894-100MG
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Vafidemstat(ORY-2001) is a potent selective brain-penetrant dual inhibitor of lysine-specific histone demethylase (LSD1 KDM1A) and MAO-B with IC50 values of 105 nM and 58 nM respectively It shows potential for treating memory deficits and behavioral alterations in neurodegenerative and psychiatric diseases
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Selleck Chemical LLC S55746 S8759-5MG
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S55746 (S 055746 BCL201) is a novel orally active BCL-2 specific inhibitor (Ki 1 3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1 BFL-1 (BCL2A1/A1) The selectivity of S55746 for BCL-2 versus BCL-XL ranges from 70 to 400 folds
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Selleck Chemical LLC Luteolin 50mg 491-70-3
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Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Sigma Aldrich Fine Chemicals Biosciences Torin2 >=98% (HPLC) | 1223001-51-1 | 5MG
Torin2 >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 432.4 | 1223001-51-1 | 5MG
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Medchemexpress LLC Ferroptosis-IN-8 | 50MG
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Ferroptosis-IN-8 | 50MG
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Selleck Chemical LLC ME-344 S9736-5MG
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ME-344 is a synthetic metabolite of NV-128 a potent inhibitor of mitochondrial oxidative phosphorylation (OXPHOS) complex I disrupting ATP generation and oxygen consumption It also inhibits mTOR by downregulating the AKT/mTOR pathway exhibiting anticancer activity by inhibiting cell growth and viability in leukemia cell lines with IC50 values of 70 260 nM
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AdipoGen Ibudilast (10 mg)
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Chemical. CAS: 50847-11-5. Formula: C14H18N2O. MW: 230.3. Ibudilast is a non-selective PDE (phosphodiesterase) inhibitor found to have anti-inflammatory activity primarily targeting the peripheral immune system and in the CNS via attenuation of glial cells.Ibudilast is an inhibitor of phosphodiesterase 4 (PDE4; IC50s = 54, 65, 239 and 166nM for PDE4A-D, respectively), PDE3A, PDE3B and PDE5A (IC50s = 1600, 2700 and 3510nM, respectively) and has been shown to act as a toll-like receptor 4 (TLR4) antagonist. Ibudilast is an allosteric inhibitor of macrophage inhibitory factor (MIF), which regulates the immune response known to drive inflammation and the cytokine storm. Overexpression of MIF is linked to multiple disease, including ARDS, asthma, rheumatoid arthritis, lupus and multiple sclerosis. Blocking the effects of MIF can protect patients with COVID-19 from developing ARDS.
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